Dermial is designed to improve the effectiveness of standard HA, Daniel Martínez Puig, director of human and animal health research and development, told NutIngredients that the new Studies have shown visible improvements in aging skin.
The first human clinical trial conducted with this ingredient investigated the effects of 60 mg of Dermial per day or a placebo over 12 weeks in 60 women between the ages of 35 and 65.
Although the results have not yet been published, they suggest that the supplement improves skin hydration and reduces wrinkles.
healthy aging skin
Hyaluronic acid is attracting attention from consumers and industry. According to the FMCG Gurus Healthy 2022 Aging Skin Report, 34% of consumers associate hyaluronic acid ingredients with skin health, and data from Future Market Insights predicts that the hyaluronic acid personal care products market will grow from 2023 to 2033. It is predicted to grow by 8% during that period.
Naturally occurring polysaccharides are present in the dermis and epidermis of the skin, and their main function is to bind water to collagen, trapping water and keeping the skin hydrated.
Hyaluronic acid levels decrease with age, which can cause loss of elasticity, increased dryness, and fragility. This suggests the need for supplements, Martinez-Puig noted, explaining that hyaluronic acid supplements are absorbed in the intestines and accumulate in connective tissue, including the skin.
The dermis contains high concentrations of HA (60-75%), as well as other components such as sulfated glycosaminoglycans and collagen, which work synergistically to improve the results of standard HA supplements. designed to improve. Previous researchshows that Dermial can improve type I collagen by 48% compared to fermentation-derived HA.
As Martinez-Puig explained, this ingredient is positioned to appeal to consumers interested in the growing category of “ageless”.
“The results we saw are consistent with this anti-aging trend of increasing wrinkles, decreasing skin hydration, and increasing dryness, similar to the aging process,” he said. “But our results point to a true rebalancing in the aging process.”
skin results
Martinez Puig previewed the latest research results, noting that daily dermal supplement consumption increased skin brightness by 20% in 6 weeks and 34% in 12 weeks.
A statistically significant difference was also observed in wrinkle reduction between the Dermial and placebo groups after 6 weeks. Additionally, stratum corneum (outermost layer of the epidermis) hydration, dryness, skin temperature, and erythema index (skin redness) were significantly improved in the dermal group at 6 weeks compared to baseline.
Participants’ perceptions also improved, as noted by Martinez-Puig, consumer satisfaction was significantly higher for women who took the supplement (69%) compared to the placebo group (42%) .
previous in vitrothe studyCompared to standard HA, Dermial was found to improve collagen type I synthesis, support human dermal fibroblast (HDF) cell proliferation at significantly higher rates, and increase HEK cell migration. did.
“This study shows that Dermial has a regenerative effect on the dermal and epidermal layers of the skin and can support dermal maintenance and functionality better than standard HA,” said Martinez-Puig.
“This human clinical trial has demonstrated superior efficacy in terms of collagen I production.”
journal: Journal of Research Dermatology, 2024.(in press).
Author: Galvez-Martin, P et al.
