Cosmetic and personal beauty care ingredient manufacturer TriNutra has created B’utyQuin, a cold-pressed black cumin seed oil ingredient. clinical trialMay improve and protect skin and scalp health. Its ingredients are “Cold-pressed black seed oil (BSO) standardized to 3% thymoquinone, a key phytonutrient, and low in free fatty acids (<2%) to maintain purity, quality, and stability.” said Dr. Riki von Oppen Bezalel, Director of Business Development at TriNutra.
The potential benefits of B’utyQuin are numerous, as detailed on the TriNutra website.Promotes mitochondrial function that declines with age, optimizes and improves cellular respiration and energy production, improves metabolism resulting in more water molecule formation and barrier repair, and enhances the action of antioxidant enzymes. Improves and removes free radicals.”
Regarding this ingredient, Dr. von Oppen Bezalel says:B’utyQuin has been shown in vitro and clinically to have antibacterial, antioxidant, anti-inflammatory, and mitochondrial function-improving properties to improve and protect skin and scalp health.”
To learn more about B’utyQuin, including its research and studies regarding its effectiveness as a cosmetic ingredient, CosmeticsDesign spoke to Dr. von-Oppen Bezalel for his insight.
Microbiome support research
To establish the validity of B’utyQuin supporting “”Maintenance of healthy skin and gut microbiota through antibacterial and antifungal activity against pathogens” said Dr. von Oppen Bezalel. in vitro studieswas carried out.Four black seed oil products of different origins with different contents of thymoquinone and free fatty acids were investigated.” As detailed in the study, “There are ongoing efforts to find alternatives to antibiotics for the treatment of various pathological conditions.,”,”The development of antibiotic-resistant microbial strains makes the effort even more difficult”
Therefore, the study continued as follows.The ability to strongly inhibit the growth of important microorganisms that cause the most common skin infections suggests that cold-pressed N. sativa oil has an important role as an alternative and safe antimicrobial agent. It also helps balance the skin and gut microbiome for good health.and health support”
Various analyzes were conducted and the study concluded that among the four products tested:B’utyQuin had excellent ability to inhibit Malassezia furfur, Candida albicans, and Staphylococcus aureus overgrowth.” said Dr. von Oppen Bezalel.
“In two other separate studies” continued Dr. von Oppen Bezalel.When comparing B’utyQuin (standardized BSO) and non-standardized BSO, B’utyQuin was clearly superior in inhibiting the growth of Propionibacterium acnes while non-standardized BSO was not.” She further explained:Some of these microorganisms are commonly found in healthy skin and gut flora, but when overgrown they can become infection-inducing microorganisms and disrupt microbiome homeostasis. .”
She summarized that analysis of these studies showed that:The composition and ratio of thymoquinone and free fatty acids play a major role in the biological activity of BSO, and therefore B’utyQuin was found to be a safe antibacterial alternative and possibly Preventive and protective care against acne breakouts and care for maintaining healthy microbiome balance and diversity”
Clinical trials investigating anti-inflammatory effects
Additional Publication of human clinical trials“We further investigated B’utyQuin as a powerful anti-inflammatory, antioxidant, and antimicrobial agent for cosmetic and dermatological applications by testing its efficacy, safety, and suitability as a topical active ingredient.” said Dr. von Oppel Bezalel. In her research she explained:B’utyQuin’s effectiveness against irritated, itchy, scaly skin and scalp, microorganisms often associated with seborrheic dermatitis, Malassezia furfur, Candida albicans, and Staphylococcus aureus, for mild to moderate seborrheic skin. It was studied in humans with flames.”
As detailed in the study, “This blinded, controlled clinical trial demonstrated that topical application of scalp serum significantly improved scalp inflammation, erythema, itching, desquamation, and overall scalp health compared to baseline.” says Dr. von Oppel Bezalel.The results showed that topical application of 5% B’utyQuin Scalp Serum for 28 days significantly improved the oiliness, inflammation, and itchiness of participants’ scalps.” The study authors concluded:It has the potential to be a safe and effective alternative to conventional antimicrobial preparations currently used for seborrheic dermatitis, skin and scalp discomforts and diseases.”
Clinical trials to study anti-aging effects
a Published Placebo Controlled Clinical TrialsIt was also conducted to investigate.regulation of mitochondrial biogenesis, ATP production, oil droplet size, and adipocyte energy expenditure; [which are] It is also thought to be involved in the effects of BSO on acne and seborrhea symptoms on the skin and scalp.” said Dr. von Oppel Bezalel.
To determine the effectiveness of an ingredient regarding its potential anti-aging effects,B’utyQuin was studied in vitro to elucidate mechanisms related to mitochondrial biogenesis and activation“was.Subsequent clinical studies were conducted to establish the safety, suitability, and efficacy of 3% B’utyQuin as a topical anti-aging cosmetic product for human skin.” she explained.
The 28-day study was conducted on 22 healthy male and female subjects with all skin types between the ages of 35 and 65, with B’utyQuin cream applied to half the face and a placebo applied to half the face. I applied it. The other half was used throughout the study period, after which effectiveness was assessed using ‘.Various standard dermatological testing techniques and equipment” the study details.
The study determined that:As a topical application, B’utyQuin produces statistically significant and visible improvements in skin hydration, brightness, firmness, and elasticity over a 28-day period when compared to a placebo cream, resulting in a more flawless appearance. We got the look.” said Dr. von Oppel Bezalel.
Therefore, she concluded:These results support the mechanisms associated with the in vitro observed mitochondrial biogenesis and activation effects of BSO, as well as its antioxidant and anti-inflammatory effects.”
Although much is still unknown about cold-pressed black cumin seed oil, the results of this study strongly suggest that this ingredient may be useful as a cosmetic ingredient in the formulation of a variety of skin and hair care products. Masu.
