To illustrate the usefulness of GOED’s new Clinical Research Database (CSD)the report provides a detailed overview of previous research on psoriasis and dermatitis.
Negative effects on skin health were one of the early discoveries of omega-3 metabolism research. Specifically, severe skin damage was observed in animal models when metabolic pathway enzymes were disrupted or removed by EPA and DHA.
Since then, scientific evidence has evolved to show that omega-3s can help regulate skin oil production, improve balanced hydration, soothe breakouts, soften rough skin, and soothe inflammation. research suggests.
psoriasis
Psoriasis, which affects 125 million people worldwide, is considered a chronic inflammatory skin disease and is often accompanied by other comorbidities such as cardiovascular disease, kidney disease, and other inflammatory diseases. there is.
Research on this topic continues to this day, but The results are contradictory. but, Recent 2020 systematic reviewsIt has been found that fish oil/EPA and DHA omega-3, when combined with conventional treatments, can improve lesion area, skin lesion severity, and quality of life in psoriasis patients.
The majority of research in this area to date has been completed with middle-aged adults. Some patients in the study had mild to severe psoriasis. Dosages given in studies tend to be higher because they are more effective in treating medical conditions.
A search of CSD revealed 41 studies on ‘psoriasis’ published between 1986 and 2020, of which 31 (76%) were intervention studies. The number of participants in each study ranged from 9 to 221, but most studies had fewer than 100 participants.
Most articles related to psoriasis (87%) presented a positive abstract conclusion, while 13% were neutral.
Dosage and results
One study utilized a dose of 640 mg/day of EPA+DHA and reported significant differences in psoriasis, scaling, psoriasis area, and severity index between baseline and study end in the omega-3 group. Ta.
Eleven studies conducted doses ranging from 1,800 to 6,000 mg/day.
At this dose, seven studies found significant differences in psoriasis, scaling, and psoriasis in the omega-3 group between baseline and final time point.
Five studies found significant differences in psoriasis area and severity index between baseline and final time points in the omega-3 group.
The three studies found no differences in psoriasis area, severity index, or psoriasis severity.
One study used intravenous EPA+DHA and found a significant difference in psoriasis between baseline and week 8 in the omega-3 group.
Five studies did not provide a clear EPA+DHA dose.
One study using topical ointments containing 1% and 10% EPA+DHA found significant improvements in psoriasis, scaling, psoriasis area, and severity index.
One study, where dosage was not listed, found significant differences in psoriasis area and severity index between the omega-3 and placebo groups when comparing change from baseline.
dermatitis
It is estimated that 115 million people worldwide suffer from eczema or atopic dermatitis.
Dermatitis is said to be an allergic disease that commonly occurs along with asthma, allergic rhinitis/hay fever/seasonal allergies, eczema/atopic dermatitis, and food allergies. Symptoms include itchy skin, dry skin, and rash.
A total of 52 studies on “dermatitis” were found, of which 38% were intervention studies, 27% were reviews, and 35% were cohort or case-control studies.
Additionally, the majority of studies investigating dermatitis focused on maternal nutrition during pregnancy and child outcomes between 6 months and 3 years of age.
This information is important when considering the results of the study, and caution should be taken in generalizing as this information only pertains to this specific population studied to date.
