Researchers in a randomized, double-blind, placebo-controlled clinical trial observed significant results in just two weeks with doses as low as 30 mg/day of wheat polar lipid complex in a subgroup of 31 menopausal women did.
According to the study results, ceramoside increased skin hydration by 19% and improved skin elasticity by 18% after 56 days compared to placebo. Volunteers in this study also reported positive effects on rough skin and skin smoothness.
“Menopause poses unique challenges to a woman’s physical and mental health,” said Alice Barbier, Active Ingredients Product Manager for Nutritional Activities at Cepik, adding, “In particular, the “The hormonal changes that occur can lead to decreased skin thickness, loss of elasticity, and increased dryness.” and vulnerability to various skin problems. The growing demand for nutraceutical solutions and the trend towards ceramides makes wheat phytoceramides a natural and effective solution backed by strong scientific evidence. ”
Menopause and skin health
The number of women over the age of 50 is expected to increase by 67.5% worldwide, from 985 million in 2020 to 1.65 billion in 2050 (Grand View Research, Menopause Market Report, (November 2023), women are expected to spend up to a third of their spending. Living post-menopause.
More than 40 types of menopausal and postmenopausal symptoms and signs have been identified, from hot flashes and mood swings to decreased sex drive, hair and skin problems, and even depression.
This biological process is characterized by a decrease in the levels of hormones, especially estrogen, which play an important role in maintaining skin health.
Collagen level is Skin rapidly decreases during early menopauseThe first five years will see an average reduction of 30%, followed by a further 2% reduction each year for the next 15 years. Additionally, menopausal skin tends to be more fragile, making it more susceptible to damage and irritation.
Percentage occupied by ceramide 50% of fatouter layer (stratum corneummatrix) plays an important role in maintaining good levels of hydration of the skin while protecting it from attack. However, the hormonal changes induced by menopause directly affect ceramides in the skin, affecting its production and causing itching, dryness, and wrinkles.
latest evidence
The 56-day study included Cosmetic Dermatology Journal,72 participants were randomly assigned to two treatment groups: WPLC oil (WPLC-O) or WPLC powder (WPLC-P) and a placebo group.
Oral supplements consisted of 70 mg/day WPLC-O or 30 mg/day WPLC-P, providing equal amounts of sphingolipids and digalactosyl diglyceride (DGDG).
Evaluations were performed on day 0 (D0), day 14 (D14), day 28 (D28), and day 56 (D56). An additional evaluation was performed on day 112, 56 days after the end of oral intake (post-D56).
To avoid possible interference from cosmetics, subjects were provided with a neutral cosmetic cream (devoid of any cosmetic claims). Its use (morning and night) began 5 days before D0 and throughout the study.
The following efficacy endpoints were assessed at each visit: CM 825 Moisturizing the cheek skin using a corneometer. Transepidermal water loss (TEWL) using Tewameter TM 300. Cheek skin elasticity measured with MPA 580 Cutometer. Skin topography of crow’s feet wrinkles evaluated using Primos CR. and tape stripping for lipidomic analysis using Corneofix in D0 and D56.
Participants also completed a 12-item questionnaire regarding product acceptability and effectiveness.
In the placebo group, no significant changes in the assessed parameters were observed over time, whereas in the group taking the supplement, skin hydration, TEWL, skin elasticity, skin smoothness and roughness, and wrinkle depth decreased. Improvements were seen.
Focusing on the postmenopausal subpopulation of subjects, the effects of the supplement were similar to those for the group as a whole.
Although the improvement in skin condition was not maintained three months after the end of the supplement intake, the researchers said this confirmed that the effect could be directly attributed to the supplement.
“These results demonstrate the nutritional value of WPLC as an ingredient to improve skin hydration and signs of aging, even though further research is needed to elucidate the precise mechanism of action associated with WPLC’s clinical benefits.” ”, the study concludes.
sauce: Cosmetic Dermatology Journal
Doi: 10.1111/jocd.16130
“A dietary supplement containing wheat polar lipid complex improves skin conditions in women with dry skin and mild to moderate skin aging.”
Author: C. Kern et al.
