Recent research published in the Scientific Journal cosmetics It was found that combining oral probiotics with topical ectoine and sodium hyaluron showed a significant improvement in visible signs of skin aging.
Over the course of eight weeks, researchers tracked changes in hydration, elasticity, radiance, and wrinkle depth. A cohort of 96 participants took daily probiotic blends (Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, and Lacticaseibacillus rhamnosus LRH020) While applying topical serum containing ectoine and cream and multiple weight hyaluronan compounds.
We spoke to author Vincenzo Nobile, R&D director at Comprife Italia, leading the way to his insights and important takeaways.
Initial and lasting effects
The study reported a 9.2% reduction in wrinkle depth, a 16.6% increase in skin hydration and a 19.1% increase in skin brightness just an hour after applying the cream, the researchers said the study showed rapid effects.
These early results continued to improve over the next few weeks. By the end of the study, participants using both supplements and topicals saw “decreased wrinkle depth, water loss in cranial relatives (indicating improved skin barrier function and condition), protoporphyrin distribution (associated with impurity removal), and prominence of skin sebum content, elasticity, stretch, flow, and a prominent atmosphere of the company.”
“Our findings clearly demonstrate the effectiveness of probiotic intake in combination with topical ectaine and sodium hyaluronate in enhancing skin health and reducing signs of skin aging,” the researchers said.
Microbiome-related mechanisms
One of the central findings of the study was the role of the microbiota. Participants who used both supplements and topical products showed an increase in certain bacteria that was linked to healthier, youthful skin. Proteobacteria, Cucci bacteriaAnd in the intestines, Jemera.
According to the report, the relative abundance of “increases of Jemera, Cutiebacteriumand Acinetobacter What we observed in the active group is related to the attributes of young skin,” suggests a strong link between microbiome support and skin appearance.
Insights from the lead research authors
In an interview, Nobile described the results as “an accelerated benefit in improving skin appearance,” saying, “the improvement in wrinkle depth in week 4, week 4 is comparable to the effects seen with a single treatment in week 8.”
He highlighted the effects on barrier function and hydration. “Skin moisturizing increased about three times compared to the placebo group. This enhanced hydration was associated with improved barrier function.
The treatment also “respects natural skin microbiomes and has an increase in Cutibacterium, a genus that has young skin properties in the scientific literature,” he added.
Impact on the industry
The findings may inform new product developments in the cosmetics and dietary supplement sector. Nobile explains the results “enhance the growth trends of integrated ‘inside-out’ skincare solutions,” highlighting “the possibility of preventive aging strategies that are particularly attractive to young demographics seeking to delay the onset of visible signs of aging.”
He added that the study paves the way for interdisciplinary, science-driven skin health solutions that bridge dermatology, nutritional and cosmetic sciences.
Limitations and Considerations
Although the results are promising, the study authors acknowledged some limitations. In the study sample, only Caucasian subjects ages 45-65 years old were accompanied by mild to moderate facial aging, which could limit generalization. Furthermore, this study did not include post-treatment follow-up to assess the persistence of efficacy after product discontinuation.
Despite these limitations, the design and integration of objective skin assessment and microbiome analysis of this study provides a strong foundation for further research and product innovation in the aging market.
As Nobile concluded, these results show that the beauty of the inside out is “more than a trend… it’s a move towards accuracy, prevention, and long-term balance” and “a new era of skin health where consumers play an active role in overall health… it becomes a new standard for those seeking authentic, lasting transformation.”
sauce: cosmetics, 2025, 1234. doi: 10.3390/COSMETICS12020034“Skin anti-deposition and skin health benefits of probiotic ingestion combined with topical ectoine and sodium hyaluronate: a randomized, double-blind, placebo-controlled trial.” “Author: V. Nobile, et al.
